这个是某妹子托我买的，因为贴剂效果要比口服来得好而安全，然后我就选了剂量最大的一种：100mcg(0.1mg)/每24小时，因为不同剂量价格都差不多- -像我这么小农的总是觉得越大碗越好...
按照非专业换算，一片Estradot 100贴片能提供每天约3-4mg补佳乐的同等剂量（补佳乐生物利用率为3%，自己算下？），这个剂量是相当大滴了，所以某些妹子别觉得0.1mg剂量小贴个好几片，没必要。（这里更正一下，我关于这点求证于一个学医的妹子，其原话是：我觉得不能完全画等号，美国的指南讲雌二醇口服的话一天要6mg，但是100ug的贴剂每周只要两贴，三天半换一次，前提是没有去势，所以1片就可以了，不过雌二醇致血栓风险小，而且经皮给药会进一步降低血栓风险，贴2片也未尝不可）---一片够了，多了个人觉得是浪费-。-

别的妹子有兴趣可以买几片试试，顺便反馈一些信息给我我最欢迎了！
至于价格呢，就别为难我了~我是最低价了，至于是否正品这种问题就别拿来惹我了~

对口服类副作用有顾虑的妹子，可以试试这种给药方式的，据说是最好但又最贵的..-。-orz..

说明书写着用量是3-4天用一片，不是别的卖家说的必须要求严格在3天半准点更换，但也请注意把握时间，否则可能会出现不规则出血，TS妹子的话没这个顾虑，但为了保证血浓度稳定，也要注意哦~

以下是我根据外文原文翻译来的（我发现很多家卖这类产品的都只顾吹嘘效果，并不会把商品各方面信息介绍清楚，在其他店购买的妹子也可以看看下面说的参考一下），这毕竟不是面膜或者什么普通的外用美容品，--有错别字请谅解，有错误翻译请店主更正，有个人建议加注部分仅供参考：

以下为原文：

Estradot general information

What is Estradot used for@

Estradot 100 is a transdermal delivery system (skin patch) containing oestrogen that is used as a short-term hormone replacement therapy (HRT) to substitute for a lack of oestrogen production by the ovaries that happens during menopause or following surgical removal of the ovaries. Using Estradot 100 patches helps relieve symptoms of menopause caused by oestrogen deficiency, such as hot flushes, night sweats, sleeplessness, vaginal dryness, headaches, mood swings, lack of concentration and loss of energy. Estradot 100 is also used to help prevent postmenopausal bone loss (osteoporosis) and reduce risk of fracture. Estradot 100 stimulates the development of female sexual characteristics, and is used as part of a transgender hormone therapy for male to female transsexuals.

How does Estradot work@

Estradot 100 is a skin patch containing the active ingredient oestradiol, the major and the most active form of the female hormone oestrogen. When you apply the patch to your skin, the oestradiol diffuses out of the patch through your skin and into your blood, delivering a dose of 100mcg oestradiol per day. Oestrogen is a steroid hormone produced by the ovaries that binds to specific receptors inside oestrogen-responsive cells and stimulates them to make proteins involved in producing secondary sexual characteristics, such as breast development and in regulating the menstrual cycle. Oestrogen also has several other actions in various metabolic processes including maintaining bone mass and lipid (fat) metabolism. Because the oestadiol in Estradot 100 enters your blood directly and continuously, it is not metabolised (broken down) by the liver, as happens when you take oral oestrogen tablets, which means that Estradot 100 patches are effective at a lower dose and provide more even blood levels similar to the natural release of oestrogen by the ovaries.

What Estradot doses are available@

Estradot patches are available in 4 strengths, each in packs of 8 or 24 patches:

• Estradot 37.5 contains 0.585 mg of oestradiol in each patch and releases 37.5 mcg oestradiol into your blood per 24hours
• Estradot 50 contains 0.78 mg of oestradiol in each patch and releases 50mcg oestradiol into your blood per 24hours
• Estradot 75 contains 1.17 mg of oestradiol in each patch and releases 75 mcg oestradiol into your blood per 24hours
• Estradot 100 contains 1.56 mg of oestradiol in each patch and releases 100mcg oestradiol into your blood per 24hours

What does Estradot contain@

The active ingredient in Estradot 100 is oestradiol (1.56 mg of oestradiol in each patch, delivered at 100mcg per day), which is the most active form of the female hormone oestrogen and is responsible for the development of female sexual characteristics and regulation of the menstrual cycle. Estradot 100 transdermal delivery system (skin patch) consists of a rectangular patch with rounded corners, comprising a pressure-sensitive adhesive layer containing estradiol, with a translucent polymeric backing on one side and a protective liner on the other. The adhesive matrix contains acrylic adhesive, silicone adhesive, oleyl alcohol, dipropylene glycol, povidone. The backing layer contains ethylene/vinyl acetate copolymer, polyethylene, vinylidene/vinyl chloride copolymer, polyethylene, ethylene/vinyl acetate copolymer co-extruded film. The release liner (to be removed before application) is a fluoropolymer-coated polyester film.

Treating symptoms of menopause with Estradot

Estradot 100 substitutes for the loss of oestrogen production by the ovaries that occurs during menopause and is the cause of symptoms such as hot flushes, night sweats, sleeplessness, dry vagina, headaches, mood swings, lack of concentration loss of energy and bone loss (osteoporosis). Estradot 100 is a transdermal delivery system (skin patch) that contains oestradiol, an active form of the female hormone oestrogen that alleviates moderate to severe menopausal symptoms.

Estradot for hormone replacement therapy (HRT)

Estradot 100 is a transdermal delivery system (skin patch) containing oestrogen that is used as a short-term hormone replacement therapy (HRT) to substitute for a lack of oestrogen production by the ovaries during the menopause. Estradot 100 is used to relieve symptoms of menopause caused by oestrogen deficiency, such as hot flushes, night sweats, sleeplessness, vaginal dryness, headaches, mood swings, lack of concentration and loss of energy. Estradot 100 is also used to help prevent postmenopausal bone loss (osteoporosis), which is also caused by lack of oestrogen, and reduce risk of fracture.

Estradot for transgender treatment

Estradot 100 can be used as part of a gender reassignment program for male to female transsexuals, by providing a source of oestradiol, an active form of the female hormone oestrogen. Estradot 100 is a transdermal delivery system (skin patch) for oestrogen that stimulates the development of female secondary sexual characteristics, such as breast development and also induces metabolic changes such as fat distribution to redefine the general body shape.

Estradot for feminising hormone therapy

Estradot 100 patches contain oestradiol, the most feminising form of the female hormone oestrogen, which provides a very effective means of feminisation when used as part of a gender reassignment program for male to female transsexuals. Estradot 100 is a transdermal delivery system (skin patch) for oestrogen that stimulates the development of female secondary sexual characteristics, such as breast development and also induces metabolic changes such as fat distribution to redefine the general body shape, while at the same time overriding the effects of testosterone. The consistent and prolonged release of oestadiol provides an effective approach to feminising hormone therapy.

What are the side effects of Estradot@

The most frequently reported side effects when using Estradot 100 patches are: itching under the patch, reddening of the skin after the patch has been removed (but this usually disappears within a few days), breast tenderness, breast pain, abdominal pain, nausea, oedema, and headache, skin rash and itching, insomnia and depression. More severe side effects include changes in liver function at higher doses.

What are the health risks of Estradot@

Long-term HRT with Estradot 100 does have associated health risks, including an increased risk of breast cancer, endometrial cancer, stroke and deep vein thrombosis. For women with an intact uterus adding a progestogen to an oestrogen replacement regimen like Estradot 100 patches is recommended to reduce the risk of endometrial cancer. There is also an increased risk of developing probable dementia in postmenopausal women 65 years of age or older.

When should Estradot not be used@

You should not use Estradot if you:

• have a past or family history of carcinoma of the breast, endometrial carcinoma or liver disease
• have deep venous thrombosis, thromboembolic disorders, cerebral vascular accident associated with oestrogen use
• abnormal genital bleeding of unknown cause
• are pregnant or planning to become pregnant
• are allergic to oestradiol or any of the ingredients in Estradot patches
• are taking other medications that may interact with Estradot, such as anticonvulsants like phenytoin and carbamazepin, anti-infectives like rifampicin, rifabutin, nevirapine, efavirenz, some medicines to help you sleep, including barbiturates and meprobamate or preparations containing St John's Wort

How should Estradot be used@

Estradot 100 patches can be used continually (which means you will usually have a patch on all the time) or in cycles (interrupted for one week after every 3 weeks) as recommended by your doctor. You should apply new patch twice weekly (every 3 or 4 days) and there are 8 patches in the packet, enough for a 4-week cycle.

Each patch should be used only for 3-4 days and then changed and only one patch should be worn at any time.

1. Before you apply your patch, make sure your skin is clean and dry and is not oily, broken or irritated.
2. Remove the protective liner from the adhesive side of the patch and apply the patch to your skin either on your lower abdomen, hips or buttocks (areas that remain covered) but never on your breasts. Do not put the patch on your waistline where tight clothes may rub it and avoid areas where the skin is hairy or folded or the patch may not stick.
3. Press the patch firmly in place with the palm of the hand for about 10 seconds and make sure the patch sticks well, especially around the edges.
4. Leave the patch in place for 3-4 days and then remove it and replace with a new patch straight away or as advised by your doctor.
5. Apply the next patch to a different part of your body as you should not use the same area of skin twice running.
6. If your patch accidentally falls off, dry your skin and reapply it or apply a new patch for the remainder of the 3-4 days dosing period.

How long should you use Estradot@

Estradot 100 patches can be used continually or in cycles (interrupted for one week after every 3 weeks) for as long as recommended by your doctor.

Missed dose of Estradot

Estradot 100 patches are intended to last for 3-4 days. If your patch accidentally falls off, reapply it or apply a new patch for the remainder of the 3-4 day dosing period. If you lose a patch or forget to replace it for several days, irregular bleeding may occur. Replace the patch as soon as possible.

How should Estradot be stored@

Keep Estradot 100 patches in their protective pouch until you are about to use one. Store in a cool dry place below 25°C.